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GLP-1 Side Effects and Quick Tips for Managing Them
Lucas Veritas
May 15, 2025
GLP-1s like all medicine can cause side effects. Gastrointestinal symptoms are the most common, affecting up to 70% of users. While most side effects are manageable, about 5% of people stop treatment because the symptoms become too uncomfortable.
This post covers the most common side effects from Ozempic, Wegovy, Mounjaro, Zepbound and how to handle them.
I've sorted the fixes by severity to keep it simple and make you feel better faster, whether you're taking Semaglutide or Tirzepatide based options.
Disclaimer: This is for informational purposes only and does not constitute medical advice. Always consult your doctor or healthcare provider about any side effects, concerns or changes to your medication.
Nausea - Most common side effect. Hits up to 70% of users.
Constipation - Affects around 20-30%. Can last weeks.
Vomiting - Less common than nausea, seen in 5-15%.
Diarrhea - Reported by 9-22% of users.
Appetite Loss - Happens in up to 40%. Part of how the drug works.
Abdominal/Stomach Pain - Shows up in up to 20%.
Indigestion - Hits 5-12%, usually early on.
Headache and Migraine - Affects about 5-10%.
Dizziness - Reported in 5-7%, often tied to low food intake.
Injection Site Reaction - Happens in 2-4%. Mild redness or itch.
Fatigue - Hits around 5%
Bloating - Varies but is common early.
Metallic Taste - Not well-studied, but common in user reports.
Hair Loss and Thinning - Rare, but anecdotally rising. Often linked to rapid weight loss.
Burping - Affects about 5-10%.
Acid Reflux - Seen in up to 8%, especially if lying down after meals.
Gas and Flatulence - Common but underreported.
Tachycardia - Rare, under 1%.
Hypoglycemia - Rare alone, but risk rises with insulin or sulfonylureas.
Stay informed, stay well
Lucas Veritas
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I’m a true GLP-1 believer. Tirzepatide (Mounjaro) user and patient advocate. I lost 100+ lbs, found my energy and gained a new mission: helping others succeed with healthy weight loss on GLP-1s |
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Disclaimer: This article reflects my personal experience and independent research. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before making decisions about your health or treatment plan.
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