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Dealing with Abdominal Pain on GLP-1? Basic Strategies Inside

Stomach pain on Ozempic, Wegovy, Zepbound or Mounjaro? Try these fast relief tips.

Author

Lucas Veritas
May 13, 2025

Stomach cramps from Zepbound, Mounjaro, Ozempic, or Wegovy are common but manageable.This memo gives you fast relief strategies, combining lived experience from real users with solid scientific research.

Disclaimer: This article is for educational purposes only and does not replace professional medical advice. Always consult your healthcare provider for personalized guidance, and seek emergency help for severe symptoms.

Basic Strategies

  • Avoid known irritants: Alcohol, caffeine, spicy foods, carbonated beverages

  • Gentle digestion: Choose easily digestible foods when pain is frequent

  • Meal timing: Small, frequent meals rather than large ones

  • Chew thoroughly: Take time to chew food completely before swallowing

  • Slow eating: Put utensils down between bites; meals should last 20+ minutes

  • Food journal: Track pain episodes to identify potential trigger foods

  • Posture matters: Sit upright while eating and for 30 minutes afterward

By Severity Level

Mild Abdominal Pain

  • Heat therapy: Warm compress or heating pad on abdomen for 15-20 minutes

  • Gentle stretching: Light yoga poses that focus on torso twisting and stretching

  • Herbal support: Chamomile, ginger, or peppermint tea

  • Abdominal massage: Gentle clockwise circular motions on abdomen

  • Mindful breathing: Deep, slow breaths focusing on expanding belly, not chest

  • Walking: Light walking to stimulate digestion and reduce gas

Moderate Abdominal Pain

  • OTC relief: Simethicone for gas pain; acetaminophen for general discomfort

  • Diet modification: Low-FODMAP approach temporarily to identify triggers

  • Antispasmodics: Peppermint oil capsules (enteric-coated) or other natural antispasmodics

  • Probiotics: May help balance gut bacteria and reduce pain

  • Dose timing: Take medication before bed to sleep through initial effects

  • Stress reduction: Stress management techniques (meditation, progressive relaxation)

Severe/Persistent Abdominal Pain

  • Medical evaluation: Consult healthcare provider to rule out serious complications

  • Medication adjustment: Discuss potential dosage reduction with doctor

  • Extended release formulations: Ask about slower-release GLP-1 options if available

  • Prescription options: Doctor may prescribe antispasmodics or pain management

  • Alternative GLP-1: Consider switching to a different GLP-1 medication

  • Specialized testing: Gastric emptying study may be needed to assess stomach function

Warning Signs (Seek Immediate Medical Care)

  • Severe, persistent pain that doesn't respond to management strategies

  • Pain accompanied by fever

  • Severe tenderness when touching abdomen

  • Inability to keep food or liquids down

  • Signs of pancreatitis (pain radiating to back, worsened when lying down)

  • Jaundice (yellowing of skin or eyes)

  • Unusual or severe bloating with pain

  • Blood in stool

Stay informed, stay well
Lucas Veritas

 

 

I’m a true GLP-1 believer.

Tirzepatide (Mounjaro) user and patient advocate.

I lost 100+ lbs, found my energy and gained a new mission: helping others succeed with healthy weight loss on GLP-1s

Disclaimer: This article reflects my personal experience and independent research. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before making decisions about your health or treatment plan.

Scientific References for this article:

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