Constipation on GLP-1 Meds: Quick Tips

Here's your super quick memo on handling constipation side effect from Ozempic, Wegovy, Mounjaro, and Zepbound. I've distilled the short essence of compensation strategies and relief, mixing together social wisdom from real people with what the science and research data tells us.

Basic Strategies

• Fiber intake: Gradually increase dietary fiber (fruits, vegetables, whole grains)

• Hydration: Drink at least 2-3 liters of water daily

• Physical activity: Daily movement helps stimulate bowel function

• Posture matters: Consider a squatty potty or footstool for easier elimination

• Medication timing: Take GLP-1 injections consistently same time each week

• Food journal: Track bowel movements and identify triggers or helpful foods

By Severity Level

Mild Constipation

• Natural foods: Prunes, kiwi, berries, apples with skin, ground flaxseeds

• Warm beverages: Hot water with lemon in the morning, coffee, warm prune juice

• Magnesium-rich foods: Spinach, almonds, pumpkin seeds, black beans

• Gentle exercise: Walking after meals, yoga poses that target digestion

• Abdominal massage: Gentle clockwise massage following the colon pathway

Moderate Constipation

• Fiber supplements: Psyllium husk (Metamucil), methylcellulose (Citrucel)

• Magnesium supplements: Magnesium citrate or magnesium oxide

• OTC options: Stool softeners like docusate sodium (Colace)

• Probiotics: Supplements or fermented foods to improve gut microbiome

• Hydration upgrade: Electrolyte drinks, coconut water, or mineral water

• Smoothie regimen: Daily fiber-rich smoothies with ground flaxseed, chia seeds

Severe Constipation

• Osmotic laxatives: Miralax (polyethylene glycol), milk of magnesia

• Prescription options: Consult doctor about prescription constipation medications

• Stimulant laxatives: Short-term use of senna or bisacodyl when needed

• Enemas or suppositories: For occasional acute relief (not for regular use)

• Medication adjustment: Work with doctor to adjust GLP-1 dosage or schedule

• Rule out complications: Medical evaluation to ensure no bowel obstruction

Check out my post where people share their personal go-to strategies for beating constipation.

Scientific References for this article:

• ^{Gastrointestinal adverse events with GLP-1 receptor agonists in type 2 diabetes: Meta-analysis of randomized controlled trials — 2021}

• ^{Gastrointestinal tolerability of GLP-1 receptor agonists: A systematic review and meta-analysis — 2018}

• ^{Constipation and altered bowel habits with GLP-1 receptor agonists: Post-marketing pharmacovigilance data — 2023}

• ^{Mechanisms of altered bowel function in GLP-1 receptor agonist therapy: Gastric emptying, intestinal transit, and hydration — 2022}

• ^{Evidence-based management of drug-induced constipation: Nutritional, pharmacologic, and lifestyle strategies — 2020}