Acid Reflux on GLP-1: Quick Tips

Acid Reflux and Heartburn from Zepbound, Mounjaro, Ozempic and Wegovy? Here’s How to Fix It

Digestive side effects like acid reflux or heartburn can sometimes put a damper on things. This post breaks down some quick, actionable tips to help you manage acid reflux while on your GLP-1 therapy.

Work with your physician to determine the best symptom management approaches, and always do so before modifying your medication regimen.

Basic Strategies

  • Posture awareness: Maintain upright position during and after meals

  • Elevated sleeping: Raise the head of your bed 6-8 inches or use a wedge pillow

  • Meal timing: Avoid eating within 3 hours of bedtime

  • Portion control: Eat smaller meals more frequently throughout the day

  • Loose clothing: Wear non-restrictive clothing, especially around the waistline

  • Weight management: Continue healthy weight loss journey with your GLP-1 medication

  • Smoking cessation: Avoid smoking and tobacco products which worsen reflux

By Severity Level

Mild Reflux

  • Food diary: Track foods and activities that trigger symptoms

  • Chewing thoroughly: Take time to chew each bite 20-30 times

  • Drinking habits: Sip water between meals rather than with meals

  • Post-meal walking: Take a gentle 10-15 minute walk after eating

  • Herbal teas: Caffeine-free chamomile, licorice, or marshmallow root tea

  • Stress reduction: Practice relaxation techniques before or after meals

Moderate Reflux

  • OTC medications: Occasional use of antacids or H2 blockers (with doctor's approval)

  • Meal spacing: Allow 4-5 hours between meals for complete digestion

  • Sleep positioning: Sleep on left side to reduce reflux during night

  • Slippery elm: Consider supplements to coat and protect esophagus

  • Abdominal breathing: Practice diaphragmatic breathing exercises

  • Pre-meal preparation: Take 1 tsp apple cider vinegar in water before meals (if appropriate)

Severe/Persistent Reflux

  • Medical evaluation: Consult doctor to rule out GERD, hiatal hernia, or erosive esophagitis

  • Medication review: Discuss timing and dosage of GLP-1 medication with your doctor

  • Prescription options: Consider prescription-strength acid suppressants if approved

  • Specialized testing: Ask about pH monitoring or endoscopy if symptoms persist

  • Physical therapy: Evaluation for potential diaphragmatic strengthening exercises

  • Advanced treatment: Discuss procedures like fundoplication if severe and unresponsive

Dietary Modifications

  • Eliminate triggers: Avoid classic reflux triggers (caffeine, chocolate, alcohol, citrus, tomatoes)

  • Limit acidic foods: Reduce intake of highly acidic foods and beverages

  • Moderate fats: Limit fatty, fried, and greasy foods that delay stomach emptying

  • Spice adjustment: Reduce or eliminate spicy foods, especially in evening meals

  • Food combining: Experiment with proper food combining techniques

  • Alkaline balance: Incorporate more alkaline foods like leafy greens and non-citrus fruits

  • Carb quality: Choose complex carbohydrates over simple, refined options

Lifestyle Adjustments

  • Meal spacing: Space meals evenly throughout the day, avoiding large gaps

  • Hydration timing: Drink fluids between meals rather than with meals

  • Sleep schedule: Maintain consistent sleep-wake cycles

  • Stress management: Practice regular stress-reduction techniques

  • Exercise timing: Avoid vigorous exercise within 2 hours of eating

  • Breathing exercises: Practice diaphragmatic breathing for 5-10 minutes daily

  • Posture training: Work on posture exercises to reduce abdominal pressure

Complementary Approaches

  • Ginger: Use fresh or as a supplement to aid digestion (1-2g daily)

  • DGL licorice: Take deglycyrrhizinated licorice tablets before meals

  • Aloe vera: Consider pure aloe vera juice (2-3 oz) between meals

  • Acupuncture: Traditional treatment for digestive disorders

  • Probiotics: Specific strains that may help with digestion and gut health

  • Melatonin: Low-dose supplement at bedtime may help strengthen esophageal sphincter

  • Zinc carnosine: Supports healing of gastric and esophageal tissue

Quick Relief Techniques

  • Baking soda: 1/2 teaspoon in 4 oz water for immediate acid neutralization (occasional use only)

  • Gum chewing: Chew sugar-free gum for 30 minutes after meals to stimulate saliva

  • Upright position: Stand or sit upright for at least 30 minutes after eating

  • Loose clothing: Immediately loosen tight belts or restrictive clothing

  • Calcium-based antacids: Provide quick relief and additional calcium (with doctor's approval)

  • Arm raising: Raise arms above head for 1-2 minutes to relieve pressure

  • Herbal lozenges: Slippery elm or marshmallow root lozenges to coat throat

Nighttime Strategies

  • Dinner timing: Eat dinner at least 3-4 hours before bedtime

  • Elevate head: Use bed risers or a wedge pillow (not just extra regular pillows)

  • Left side sleeping: Sleep on your left side to reduce reflux episodes

  • Pre-bed routine: Avoid screen time and practice relaxation before bed

  • Avoid water: Don't drink large amounts of water right before sleeping

  • Light snack option: If needed, choose a small protein-based snack instead of carbs

  • Pajama choice: Wear loose-fitting nightwear that doesn't constrict abdomen

Remember that reflux symptoms often improve as your body adjusts to GLP-1 medications and as weight loss progresses. However, persistent or severe reflux requires medical attention to prevent complications like esophageal damage.

When to Contact Your Doctor

  • Reflux symptoms persist despite implementing management strategies

  • You experience difficulty swallowing or painful swallowing

  • You notice unexplained weight loss or decreased appetite

  • You have persistent hoarseness, chronic cough, or worsening asthma

  • You experience chest pain (after cardiac causes have been ruled out)

  • You notice black, tarry stools or vomiting with blood

If you find this post useful, copy the link and share it with someone else walking the GLP-1 path. Every new reader who joins our email list makes a difference.

Stay healthy (and hungry for knowledge),
Lucas Veritas

I’m a true GLP-1 believer.

Background: Lost 90+ lbs. Found energy. Gained clarity. Read about me or get in touch

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