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- Fiber on GLP-1: Improve Digestion, Prevent Constipation, Stay Full Longer
Fiber on GLP-1: Improve Digestion, Prevent Constipation, Stay Full Longer
The role of fiber in maximizing Semaglutide and Tirzepatide benefits
Fiber is the indigestible part of plants, mainly found in cell walls and other structural components. It moves through our body like a passenger — we lack the enzymes to break it down. Instead, gut bacteria digest it at the very end of the process, in the intestines.
That’s why it’s crucial to keep this indigestible bulk moving daily. When you eat a Greek salad, fiber absorbs stomach juices and swells, pressing against the stomach walls. In response, the stomach signals the brain that you’re full, making you more likely to skip dessert.
Next, fiber enters the intestines, where it slows glucose absorption, reducing diabetes risk. It also binds to cholesterol, preventing its absorption into the bloodstream—helping lower cholesterol and reduce the risk of gallstones.
Finally, gut bacteria feast on fiber, strengthening your immune system. Plus, fiber scrubs the intestinal walls, helping prevent colon cancer.
All of this combined lowers the risk of non-communicable diseases — heart disease, stroke, cancer and diabetes. These conditions collectively cause 70% of all deaths worldwide.
Fiber on GLP-1 Medications
Fiber and GLP-1 medications can be a tricky combination. Too much fiber might leave you feeling overly full, making it hard to get enough calories, protein, or other carbohydrates — and it can lead to bloating.
On the other hand, too little (or even too much) fiber can contribute to constipation, a common side effect. Everyone reacts differently, and with your digestive system adjusting in new ways, finding the right balance takes some trial and error.
The best approach? Start slow, mix up your fiber sources daily, and gradually increase your intake.
Soluble and Insoluble
Soluble fiber comes from foods like fruit, root vegetables, oats, soy products, and legumes (beans and lentils). It dissolves in your digestive system's fluids, forming a gel-like substance. This remarkable transformation allows it to bind with cholesterol particles in your intestines before they can enter your bloodstream.
The result? Lower blood cholesterol levels—particularly that troublesome LDL cholesterol—which significantly benefits your cardiovascular health. While your heart gets the most obvious advantage, this cholesterol-lowering effect supports your entire circulatory system, from your brain to your toes.
Insoluble fiber is found in wholemeal products, corn, wheat, cereals, nuts, and seeds. Unlike its soluble counterpart, this fiber type remains largely intact as it travels through your digestive tract. Think of it as nature's internal cleansing system—it adds bulk to waste material and speeds transit time through your intestines. This "sweeping" action is particularly beneficial for bowel health, helping maintain regularity and physically cleaning intestinal walls.
Regular consumption of insoluble fiber has been linked to reduced risk of digestive cancers (colon, intestinal, stomach) and may help prevent common issues like irritable bowel syndrome, colitis, and hemorrhoids. It's essentially performing routine maintenance on your digestive highway.

How Much Fiber Do You Need?
The Dietary Guidelines for Americans recommend:
Women: 25 grams per day
Men: 38 grams per day
Or about 14 grams per 1,000 calories consumed.
How Do You Know if Your Fiber Intake is Right for You?
Check your poops — seriously. It might not be the most glamorous topic, but it’s important.
This is the perfect chance to introduce you to the Bristol Stool Chart!
Tips for Increasing Fiber Intake
✓ Consider Fiber Supplements – If your intake is consistently low, supplements like psyllium husk (Metamucil or fiber gummies) can help, but they’re not a replacement for whole food sources.
✓Choose Whole Grains – Replace refined grains like white bread and pasta with whole-grain options.
✓Include Fruits and Vegetables with Every Meal – Try to keep the skins on fruits and vegetables where possible to maximize fiber.
✓Add Legumes – Substitute the meat in meals with beans or lentils a few times a week to boost fiber and protein intake.
✓Snack on Nuts and Seeds – Instead of processed snacks, opt for nuts, seeds, or fiber-rich popcorn.
Fiber is more than just bulk — it’s a powerful tool for digestion, heart health, and disease prevention. Remember to start slow, stay consistent, and your gut (and your poop) will tell you if you’re on the right track!
Stay healthy (and hungry for knowledge),
Lucas Veritas

References:
Cann, I., et al. (2025). Gut bacteria help digest dietary fiber, release important antioxidant. University of Illinois Urbana-Champaign News.
Cleveland Clinic. (n.d.). What Is Your Gut Microbiome? Retrieved March 06, 2025.
Dietary Guidelines for Americans. (2020-2025). U.S. Department of Health and Human Services and U.S. Department of Agriculture.
Holscher, H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes, 8(2), 172-184.
Makki, K., et al. (2018). The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease. Cell Host & Microbe, 23(6), 705-715.
Stanford Center on Longevity. (2024). What is Fiber and Why is it Important for the Microbiome? Gut Health.
World Health Organization. (2024). Noncommunicable diseases. Retrieved March 06, 2025.
Yan, H., et al. (2023). The interaction between dietary fiber and gut microbiota, and its impact on pig health: A review. Frontiers in Immunology, 14, 1095740.
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