- The GLP-1 Effect
- Posts
- Breaking Through Your Weight Loss Plateau
Breaking Through Your Weight Loss Plateau
Stalling on Semaglutide (Ozempic) or Tirzepatide (Mounjaro)?
In my previous post, I explained the science behind weight-loss plateaus and why they’re key to long-term success. We covered set-point theory, which suggests your body has a preferred weight it works to maintain.
Now, let’s explore how to break through a plateau and keep moving toward your goals—you still have weight to lose.
The Key Question: Plateau vs Roadblock?
It's crucial to distinguish between two scenarios:
A weight loss plateau resulting from your body adapting to a new set-point weigh
OR
Something else standing in the way, like nutrition tweaks, activity levels or even stress.
Understanding what you’re facing is key to making informed decisions and preventing unnecessary frustration.
Scenario 1
This is a weight-loss plateau as my body adjusts to its set-point.
Here are major signs you might be hitting a real plateau:
You’ve lost about 5-10% of your body weight.
Your weight has remained stable for 8-12 weeks.
You’re feeling hungrier, despite not changing your portions or food choices.
You’ve noticed a dip in energy and feel more fatigued than usual.
A lot of your mental energy is focused on your weight.
Your clothes fit better, even if the scale isn’t budging.
You’re maintaining or even gaining muscle while losing fat.
Your body seems to be pushing back against further weight loss, despite your consistent efforts.
At least five points sound familiar? It’s likely your body has reached a true plateau — a natural part of the weight loss process.
Here’s an insightful graph from redditor rlb_12 about what a true plateau really looks like.

So, what should you do when you find yourself plateaued?
First and foremost, remember — you’re not stuck, you’re stabilizing. Your body is taking time to adjust to a new set-point, and that’s a key part of the process. Keep in mind that, on average, plateaus last 8–12 weeks.
Keep pushing forward, but be patient.
Find fresh ways to reignite your motivation.
Keep focusing on sustainable, healthy habits while allowing your body to adapt.
Just keep going and trust the process.
Scenario 2
Challenges in further weight reduction due to various factors.
There are plenty reasons why your weight loss might stall while using GLP-1 medication.
But let’s focus on the most common ones — these probably cover about 80% of the cases. Take a moment to think about each one and see how it fits into your journey.
1. Adjust Your Dosage
If you're still on a lower dose of your GLP-1 medication and your progress has stopped, it might be time to talk to your doctor about increasing your dosage. Pay attention to your "hunger window" — the number of days after your shot when food cravings return. Ideally, hunger should stay suppressed until at least day six.
While dose adjustments often seem like the first solution, it’s worth exploring other reasons first.
2. Lack of Quality Sleep
Quality sleep isn't just about feeling rested — it's essential for weight loss. Poor sleep habits can raise cortisol levels, prompting your body to store fat and triggering cravings for unhealthy foods. Sleep directly impacts our food choices, hunger levels and metabolic rate.
Aim for 7-8 hours of sleep nightly, and stick to a consistent schedule. This will help reduce stress and improve recovery.
3. You’re stressed
Chronic stress floods your system with cortisol, which can slow your metabolism and increase appetite — especially for sugary, salty and fatty foods. Stress also impacts sleep, creating a cycle that’s hard to break.
Find ways to manage stress, whether it’s through mindfulness, exercise, or simply taking a moment to breathe.
4. Vary your exercise routine
Exercise is one of the best ways to push past a plateau. You don’t need to exercise harder, just smarter. Aerobic exercises like walking, swimming or jogging reduce visceral fat, the fat stored around your organs. While you might not see this reflected immediately on the scale, it’s still crucial because visceral fat is linked to health risks like high blood pressure and insulin resistance.
Strength training is also great option because it boost metabolism and burn fat more effectively than cardio alone. Changing up your routine helps target different muscle groups and keeps your body burning fat.
5. Check your portions
Instead of obsessing over every calorie, focus on balanced meals. Your plate needs a solid foundation of protein, healthy fats and non-starchy vegetables. When you add carbs (because let's be real, we need them), go for the complex ones like oats, brown pasta or rye bread, rather than refined carbs like white bread or sugary cereals.
Balanced portions help you feel full and fuel your body efficiently.
6. You're Not Drinking Enough Water
Thirst can often masquerade as hunger, leading to overeating. Staying hydrated helps manage hunger and supports weight loss. Studies confirmed that this weight loss resulted from increased water intake, which reduced hunger and enhanced feelings of fullness.
Keep a glass of water handy, set hourly reminders, or drink a glass before meals to stay on track.
7. Timing Your Metabolic Window
When you eat might actually matter as much as what you eat. Time-restricted feeding, where you limit your eating window to 10 hours or less (e.g., 9am-7pm), is a growing area of research that shows potential benefits for weight loss and metabolic health.
Narrowing your eating window might help boost your progress.
Interestingly, eating breakfast can help balance blood sugar levels and curb cravings for sweets later on, so it’s worth experimenting with.
Conclusion
Breaking through a plateau requires understanding the underlying cause. These common factors — from medication to lifestyle habits — offer a starting point. Review each one, adjust as needed, and remember: progress takes time. Stick with it and your efforts will pay off.
Stay healthy (and hungry for knowledge),
Lucas Veritas
References:
Müller, M. J., Bosy-Westphal, A., & Heymsfield, S. B. (2010). Is there evidence for a set point that regulates human body weight?. F1000 Medicine Reports, 2, 59. https://doi.org/10.3410/M2-59
Rosenbaum, M., & Leibel, R. L. (2014). 20 years of leptin: role of leptin in energy homeostasis in humans. The Journal of endocrinology, 223(1), T83–T96. https://doi.org/10.1530/JOE-14-0358
Fothergill, E., Guo, J., Howard, L., Kerns, J. C., Knuth, N. D., Brychta, R., Chen, K. Y., Skarulis, M. C., Walter, M., Walter, P. J., & Hall, K. D. (2016). Persistent metabolic adaptation 6 years after "The Biggest Loser" competition. Obesity, 24(8), 1612-1619. https://doi.org/10.1002/oby.21538
Chaput, J. P., Drapeau, V., Hetherington, M., Lemieux, S., Provencher, V., & Tremblay, A. (2005). Psychobiological effects observed in obese men experiencing body weight loss plateau. Depression and anxiety, 22(4), 171-177. https://doi.org/10.1002/da.20111
Wilkinson, L. L., Rowe, A. C., & Hardman, C. A. (2021). Explaining the relationship between attachment anxiety, eating behaviour and BMI. Appetite, 163, 105238. https://doi.org/10.1016/j.appet.2021.105238
Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004). Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS medicine, 1(3), e62. https://doi.org/10.1371/journal.pmed.0010062
Hewagalamulage, S. D., Lee, T. K., Clarke, I. J., & Henry, B. A. (2016). Stress, cortisol, and obesity: a role for cortisol responsiveness in identifying individuals prone to obesity. Domestic animal endocrinology, 56, S112-S120. https://doi.org/10.1016/j.domaniend.2016.03.004
Willis, L. H., Slentz, C. A., Bateman, L. A., Shields, A. T., Piner, L. W., Bales, C. W., Houmard, J. A., & Kraus, W. E. (2012). Effects of aerobic and/or resistance training on body mass and fat mass in overweight or obese adults. Journal of applied physiology, 113(12), 1831-1837. https://doi.org/10.1152/japplphysiol.01370.2011
Hollis, J. H., Houchins, J. A., Blumberg, J. B., & Mattes, R. D. (2009). Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. Journal of the American College of Nutrition, 28(5), 574-582. https://doi.org/10.1080/07315724.2009.10719789
Gill, S., & Panda, S. (2015). A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits. Cell metabolism, 22(5), 789-798. https://doi.org/10.1016/j.cmet.2015.09.005
Reply